Synthesis of Nucleosides with Additional Nucleobases

Abstract

The syntheses of two nucleosides with additional nucleobases in the 2′-position are presented. The nucleosides have two- and one-carbon linkers to the additional nucleobase, respectively. The two nucleosides are synthesized from different strategies. The nucleoside with two carbons in the linker has been incorporated into oligonucleotides and showed stabilization of a tree-way junction.

Keywords:

• Double-headed nucleobase
• RNA secondary structure
• 2′-modification

The Danish National Research Foundation, The Danish Natural Research Council and The Danish Centre for Scientific Computing are thanked for financial support.