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Original Articles

Evaluating Coupling Procedures for Synthesis of Lna-Peptide Conjugates

, , , &
Pages 1501-1504 | Published online: 05 Dec 2007
 

Abstract

As initial studies of block coupling of peptides with C-terminal glycines, we have evaluated of coupling of glycine building blocks under various conditions to a preassembled solid support bound LNA-fragment. Potentially competing side reaction have been studied and we have worked out a procedure for trifluoroacetyl protection of peptides.

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