Abstract
Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4′-C-acyloxymethyl-2′,3′,5′-tri-O-acyl-β-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-β-L-threo-pentofuranose, respectively in a highly selective and efficient manner.
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We thank the Danish Natural Science Research Foundation and the Department of Biotechnology (DBT, New Delhi, India) for financial support to this work. S. K. S. and N. K. thank the Council of Scientific and Industrial Research (CSIR, New Delhi) for the award of J. R. F. and S. R. F.