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Nucleosides, Nucleotides & Nucleic Acids Volume 26, 2007 - Issue 10-12
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Original Articles

Mass Spectrometry Based Methods for Analysis of Nucleosides as Antiviral Drugs and Potential Tumor Biomarkers

Luigi A. Agrofoglio Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, Orléans, France
,
Vincent Bezy Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, Orléans, France
,
Patrick Chaimbault Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, Orléans, France
,
Raphaël Delépée Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, Orléans, France
,
Boutaina Rhourri Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, Orléans, France
&
Philippe Morin Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, Orléans, France
Pages 1523-1527 | Published online: 05 Dec 2007
 
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Abstract

The intracellular analysis of the phosphorylated metabolites of some anti-HIV nucleosides by liquid chromatography or capillary electrophoresis coupled with tandem mass spectrometry (LC-MS/MS or CE-MS/MS) has been realized on human peripheral blood mononuclear cells (PBMC), with limit of quantitation (LOQ) that allow them to be quantitated intracellularly. We described also the analysis of modified urinary nucleosides as potential tumor biomarkers.

These studies were supported in part by a grant from Agence Nationale de Recherches sur le SIDA, the SIDACTION and Bristol-Myers Squibb.

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