Abstract
Oligonucleotides modified with 2 ′,4 ′-BNA NC (N-H)/(N-Me) monomers exhibited excellent hybridizing and nuclease resistance properties. Duplex and triplex thermal stabilities were greatly enhanced by incorporating 2′,4′-BNA NC (N-H) and (N-Me) monomers and nuclease resistance was tremendously higher than that of natural oligonucleotide.
S.M.A.R. is on leave from the Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Notes
a Conditions: See Materials and Methods.
b Δ T m/mod. = changes in melting temperature per single modification.
a Conditions: See Materials and Methods.