A Highly Efficient and Selective Synthesis of 1,2,3-Triazole Linked Saccharide Nucleosides Via “Click Chemistry”

Abstract

A series of 1,2,3-triazole linked saccharide nucleosides were synthesized in high yield and selectivity via “click chemistry” of the 3′-azido-2′-deoxythymidine and the propargyl carbohydrates.

Keywords:

• 1,2,3-Triazole
• “click chemistry”
• saccharides, antiviral compounds

This work was supported by the National Natural Science Foundation of China (No. 20502009), key projects from the Ministry of Education of P. R. China, the Ministry of Personnel of P. R. China, and Jiangxi Science & Technology Normal University.