Synthesis and Biological Evaluation of Novel Selenonucleosides

Abstract

A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.

Keywords:

• Synthesis
• biological evaluation
• selenonucleoside
• 1,4-oxaselenane

Acknowledgments

This research was financially supported by an Innovation Grant (08ZZ12) from the Shanghai Municipal Education Commission.