Serum Urate, Metabolic Syndrome, and Cardiovascular Risk Factors. A Population-Based Study

Abstract

We studied the associations between serum urate levels (determined in 503 subjects from a population of 1,344 subjects living in northern Madrid) and both the metabolic syndrome (MS) (defined by the Adult Treatment Panel III criteria) and C-reactive protein (CRP, determined in 382 subjects). MS was diagnosed in 25% (95%CI, 21–28%) and was associated with hyperuricemia (p<0.001). There was a graded increase in serum urate levels with increasing number of MS components. Urate concentrations significantly correlated with waist circumference (r=0,455, p<0.01). Serum urate was not independently associated with CRP levels. This study shows that serum urate levels are associated with the presence of MS and each of its features.

Keywords:

• Serum urate
• hyperuricemia
• metabolic syndrome
• CRP
• cardiovascular risk factors

The authors thank the participants in the working group MAPA-Madrid, who made this study possible.