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Nucleosides, Nucleotides & Nucleic Acids Volume 27, 2008 - Issue 6-7
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Proceedings of the 12th International Symposium on Purine and Pyrimidine Metabolism in Man (PP07)

Modulation of AMP Deaminase in Rat Hearts Subjected to Ischemia and Reperfusion by Purine Riboside

T. Borkowski Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
,
M. Lipinski Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland
,
R. Kaminski Clinic of Cardiology and Electrotherapy, Medical University of Gdansk, Gdansk, Poland
,
E. Krzyminska-Stasiuk Clinic of Cardiology and Electrotherapy, Medical University of Gdansk, Gdansk, Poland
,
M. Langowska Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
,
G. Raczak Clinic of Cardiology and Electrotherapy, Medical University of Gdansk, Gdansk, Poland
,
E. M. Slominska Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
&
R. T. Smolenski Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland; Heart Science Centre, Imperial College London, Harefield, United Kingdom
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Pages 876-880 | Published online: 03 Jul 2008
 
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Abstract

Changes in AMP deaminase (AMPD) activity influence heart function and progression of heart disease, but the underlying mechanism is unknown. We evaluated the effect of purine riboside (Purr) on the activity of AMPD in perfused rat hearts and in isolated rat cardiomyocytes. Brief perfusion of the pre-ischemic heart with 200 μ M Purr resulted in activation of AMPD, more pronounced degradation of the adenine nucleotides, and reduced recovery of the adenine nucleotide pool during reperfusion. Brief incubation of rat cardiomyocytes with 200 μ M Purr also activated AMPD, while prolonged exposure resulted in enzyme inhibition. We conclude that Purr activates AMPD, whereas metabolites of this compound may inhibit the enzyme.

This study has been supported by the Ministry of Science of Poland (N401 101 31/2201, W-172, W-511).

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