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Nucleosides, Nucleotides & Nucleic Acids Volume 29, 2010 - Issue 3
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Original Articles

Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid Conjugate—BAA

Mingyue Tian Beijing Key Lab of Gene Engineering Drugs & Biological Technology, College of Life Sciences, Beijing Normal University, Beijing, P. R. China
,
Xiufeng Zhang Institute of Chemistry, the Chinese Academy of Sciences, Beijing, P. R. China
,
Yan Li Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P. R. China
,
Yong Ju Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P. R. China
,
Junfeng Xiang Institute of Chemistry, the Chinese Academy of Sciences, Beijing, P. R. China
,
Changqi Zhao Beijing Key Lab of Gene Engineering Drugs & Biological Technology, College of Life Sciences, Beijing Normal University, Beijing, P. R. China
&
Yalin Tang Institute of Chemistry, the Chinese Academy of Sciences, Beijing, P. R. China
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Pages 190-199 | Received 15 Dec 2009, Accepted 22 Jan 2010, Published online: 19 Apr 2010
 
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Abstract

Human c-myc gene is a central regulator of cellular proliferation and cell growth, and G-quadruplexes have been proven to be the transcriptional controller of this gene. In this study, the interaction of bile acid-amino acid conjugate (BAA) with G-quadruplexes in c-myc was investigated by circular dichroism spectroscopy, nuclear magnetic resonance (NMR) measurement, and quantitative real-time polymerase chain reaction (PCR) assay. The experimental results indicated that BAA has the ability to selectively induce the formation of parallel G-quadruplexes in c-myc, which leads to down-regulation of c-myc transcription in the human breast cancer cell MCF-7.

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