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Nucleosides, Nucleotides & Nucleic Acids Volume 29, 2010 - Issue 4-6
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Original Articles

Protection of Mouse Heart Against Hypoxic Damage by AMP Deaminase Inhibition

T. Borkowski Department of Biochemistry, Medical University of Gdansk, Poland
,
E. M. Slominska Department of Biochemistry, Medical University of Gdansk, Poland
,
C. Orlewska Department of Organic Chemistry, Medical University of Gdansk, Poland
,
S. Chlopicki Department of Clinical Pharmacology, Jagiellonian University, Krakow, Poland
,
P. Siondalski Deparment of Cardiothoracic Surgery, Medical University of Gdansk, Poland
,
M. H. Yacoub Heart Science Centre, Imperial College London, United Kingdom
&
R. T. Smolenski Department of Biochemistry, Medical University of Gdansk, Poland; Heart Science Centre, Imperial College London, United Kingdom
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Pages 449-452 | Published online: 11 Jun 2010
 
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Abstract

Clinical observation in patients with heart disease indicates that reduced activity of AMP deaminase could be protective in heart failure and ischemic heart disease. This study evaluated the effect of 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo [4,5-d][1,3]diazepin-8-ol, an AMP deaminase inhibitor (AMPDI) in the mouse heart subjected to hypoxia. ApoE/LDLR knock-out mice were subjected to reduced oxygen tension in breathing air. AMPDI was infused before hypoxia in the treated group. We observed amelioration of elcetrocardiographic changes during hypoxia in the treated group that are consistent with a protective effect.

Acknowledgments

This study was supported by the Ministry of Science of Poland (N401 101 31/2201 and W-72) and the Magdi Yacoub Institute.

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