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Nucleosides, Nucleotides & Nucleic Acids Volume 29, 2010 - Issue 4-6
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Original Articles

Cardiac Muscle AMP-Deaminase from a 10-Year-Old Male Heterozygous for the AMPD1 C34T Mutation

I. Rybakowska Department of Clinical Biochemistry and Physiology, Medical University of Gdansk, Gdansk, Poland
,
S. Bakuła Department of Rehabilitation, Medical University of Gdansk, Gdansk, Poland
,
J. Klimek Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland
,
R. Milczarek Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland
,
R. T. Smolenski Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland; Heart Science Centre, Imperial College London, United Kingdom
&
K. Kaletha Department of Clinical Biochemistry and Physiology, Medical University of Gdansk, Gdansk, Poland
Pages 453-456 | Published online: 11 Jun 2010
 
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Abstract

A C34T mutation in the AMPD1 gene is proposed to cause local or systemic augmentations in blood adenosine level and improvement of prognoses in heart diseases like congestive heart failure or heart ischemic disease. This study examines some physico-chemical properties of AMP-deaminase isolated from cardiac muscle of a 10-year-old boy heterozygote for this mutation.

Acknowledgments

This study was supported by the Ministry of Science of Poland (ST-534 and N401 101 31/2201).

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