Evaluating Chemical and other Agent Exosures for Reproductive and Developmental Toxicity

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This is a reprint of Evaluating Chemical and Other Agent Exposures for Reproductive and Develop-mental Toxicity , Subcommittee on Reproductive and Developmental Toxicity, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council © 2001 National Academy of Sciences. First published by National Academies Press. All rights reserved. This reprint published under agreement with the National Academy of Sciences.

Copies of the original book, Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity , (2001, ISBN 0-309-07316-2, 262 pages, paperback) are available from the National Academies Press, Washington, D.C., USA. The full text of this book may also be viewed online at http://books.nap.edu/catalog/10007.html.

Notes

∗ Moore, J. A., G. P. Daston, E. Faustman, M. S. Golub, W. L. Hart, C. Hughes, Jr., C. A. Kimmel, J. C. Lamb, IV, B. A. Schwetz, and A. R. Scialli. 1995. An evaluative process for assessing human reproductive and developmental toxicity of agents. Reprod. Toxicol. 9(1):61–95.

∗ The convention of using BMDL as the lower confidence limit follows the terminology proposed in the paper by Crump (1995); this has also been adopted for use in the EPA BMDS software, since it refers explicitly to the lower confidence limit value.

∗Subcommittee member Paul Foster was previously employed at a company that conducted reproductive and developmental toxicity studies on HFC-134a. Because Dr. Foster was involved in the review of those studies, he did not participate in the subcommittee's discussions and deliberations on HFC-134a.