Vitamin D₂ from Irradiated Mushrooms Significantly Increases Femur Bone Mineral Density in Rats

Abstract

A method has been optimized for the conversion of ergosterol in mushrooms to vitamin D₂, and the vitamin D-enriched mushrooms have been tested for bioavailability of vitamin D₂ using a rat model. Femur bone mineral density (BMD) of the experimental group of animals fed with vitamin D₂ (1 μg/d) obtained from irradiated mushrooms was significantly increased. Femur BMD of two groups was significantly higher. Femur BMD of the experimental group was significantly elevated compared to initial femur BMD of the study group. Data indicate that vitamin D₂ from ultraviolet (UV)-irradiated mushrooms was well absorbed and metabolized in animals.

Acknowledgments

This research was supported by an academic research grant from the National University of Singapore (R-143-000-138-112).