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Abstract
A meta-regression analysis was undertaken to evaluate the association between δ-aminolevulinic acid dehydratase (ALAD) genotypes and blood lead levels obtained from data published in various journals. In total, 15 studies were included in the final analysis. Both fixed effects and random effects models were used to undertake the pooled analysis. Using a fixed effects model, pooled estimates of mean differences of various ALAD genotypes was significant at 0.61μg/dl. Using a random effects model, the pooled estimate was also significant at 1.51μg/dl. Data indicated that certain ALAD genotypes may affect the susceptibility of humans to lead.
This study was supported by the National Key Basic Research Program grant (202CB512910), National Natural Science Foundation grant (30571619), and Natural Science Foundation of Jiangsu Province grant (04KJB310081).