Cadmium in Placenta—A Valuable Biomarker of Exposure During Pregnancy in Biomedical Research

Abstract

Rats were exposed to cadmium (Cd) during pregnancy orally (50 ppm Cd in drinking water from gestation day [GD] 1–20) or parenterally (5 mg/kg sc during GD 1–19 or on GD 16). Cadmium levels were measured in blood, placenta, and fetus at the end of exposure. Human studies comprised of two cohorts of healthy Croatian postpartum women in the continental versus coastal area; in these women, Cd levels were measured in maternal blood, placenta, and cord blood. Cadmium in rat placenta was 10-fold higher following parenteral versus oral exposure, with highest value after exposure in mid pregnancy. The values were 10-fold higher in placenta than blood, and the fetus had ≤10% of blood metal levels. Cadmium levels in human placenta noted increased values in smokers that were 10- to 20-fold higher than in maternal blood and in cord blood were very low (<0.1 ppb). In nonsmokers, different Cd levels in placenta and blood in coastal versus continental area were found due to dietary intake. Data showed that Cd in placenta is a reliable biomarker of exposure following oral and parenteral treatment during pregnancy in rats and in human biomonitoring that includes prenatal assessment. In addition, tobacco smoking is a prominent source of metal exposure. Cd levels in placenta are also a valuable biomarker of metal dietary exposure related to specific dietary habits and soil characteristics.