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Journal of Toxicology and Environmental Health, Part A
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Volume 78, 2015 - Issue 1
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Original Articles

Chromium Exposure and Germinal Embryonal Carcinoma: First Two Cases and Review of the Literature

Rossana BerardiMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, ItalyCorrespondence[email protected]
,
Chiara PelleiMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Gianluca ValeriRadiology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Mirco PistelliMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Azzurra OnofriMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Francesca MorgeseMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Miriam CaramantiMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Riccardo Mashadi MirzaRadiology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Matteo SantoniMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Mariagrazia De LisaMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Agnese SaviniMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Zelmira BallatoreMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
,
Gian Marco GiuseppettiRadiology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
&
Stefano CascinuMedical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero–Universitaria Ospedali Riuniti Umberto I–GM Lancisi–G Salesi, Ancona, Italy
 show all
Pages 1-6 | Published online: 25 Nov 2014
 
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Abstract

The aim of the study was to determine the potential role of occupational exposures to chromium (Cr) in the onset of extragonadal germinal embryonal carcinoma. The first two cases of workers in a company with Cr exposure are reported. The published scientific literature regarding the topic in peer-reviewed journals including MEDLINE and CancerLit databases was extensively reviewed. Two young patients who were coworkers in the same company, exposed to Cr, developed extragonadal germinal embryonal carcinomas. One of them also developed angiosarcoma of the mediastinum. To the best of our knowledge these are the first two cases of germinal embryonal carcinoma in patients with occupational exposure to Cr.

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