Short-term effects of ozone air pollution on hospital admissions for myocardial infarction: A time-stratified case-crossover study in Taipei

ABSTRACT

This study was undertaken to determine whether there was a correlation between ambient ozone (O₃) levels and number of hospital admissions for myocardial infarction (MI) in Taipei, Taiwan. Hospital admissions for MI and ambient air pollution data for Taipei were obtained for the period from 2006 to 2010. The relative risk (RR) of hospital admissions for MI was estimated using a time-stratified case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. For the single-pollutant model (without adjustment for other pollutants), increased RR for a number of MI admissions was significantly associated with higher O₃ levels both on warm days (>23°C) and on cool days (<23°C). This observation was accompanied by an interquartile range elevation correlated with a 7% (95% CI = 2%–12%) and 17% (95% CI = 11%–25%) rise in number of MI admissions, respectively. In the two-pollutant models, no significant associations between ambient O₃ concentrations and number of MI admissions were observed on warm days. However, on cool days, correlation between ambient O₃ after inclusion of each of the other five pollutants, particulate matter (PM₁₀ or PM_2.5), sulfur dioxide (SO₂), nitrogen dioxide (NO₂) or carbon monoxide (CO), and number of MI admissions remained significant. This study provides evidence that higher levels of ambient O₃ increase the RR of number of hospital admissions for MI.

Acknowledgments

This study is based in part on data from the National Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by National Health Research Institutes. The interpretation and conclusions contained herein do not represent those of Bureau of National Health Insurance, Department of Health or National Health Research Institutes.

Funding

This study was supported by a grant from Wang Jhan-Yang Trust Fund (WJY 2016-HR-01) National Health Research Institutes, Taiwan (EM-105-PP-08).