Catalytically and noncatalytically treated automobile exhaust: Biological effects in rats

Chronic exposure to catalytically treated or noncatolytically treated automobile exhaust significantly depressed the spontaneous locomotor activity (SLA) of rats. Exposure to H₂SO₄ alone or CO at comparable levels did not alter the SLA. Exposure to noncatalytically treated exhaust resulted in significant reductions in growth rate and food and water intake. However, these effects were not evident in the exposure to catalytically treated exhaust or in the control H₂SO₄ and CO exposures. Blood acid‐base analyses indicated that exposure to either catalytically treated exhaust or H ₂ SO ₄ elicits a metabolic alkalosis, while exposure to CO alone results in a metabolic acidosis. All acid‐base parameters were within the normal range several weeks after the termination of exposure.