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Abstract
A mechanized wheel was constructed for use in evaluating the interaction of exercise and gaseous pollutants such as O 3 and NO 2 . Immediately after the pollutant exposure, both exercised and nonexercised female mice (CD‐1) were combined with controls, challenged with an aerosol of viable Streptococcus pyogenes (group C), and then observed over a 15‐d period for incidence of mortality. Exposure to O 3 at 196 μg/m 3 (0.1 ppm) or 590 μg/m 3 (0.3 ppm) while exercising yielded mortality rates that were significantly higher than those observed in the O 3 groups that were not exercised. With exposure to NO 2 at 5640 μg/m 3 (3 ppm), exercise produced a significant enhancement in mortality over the other treatment groups. These studies show that exercise can affect the mortality observed in this model system and indicate the need for establishing safe exposure levels of pollutants as a function of the activity level of the exposed population.
