Investigation of hyperkeratotic activity of polybrominated biphenyls in firemaster FF‐1

L. L. Needham Toxicology Branch, Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Services, U.S. Department of Health and Human Services, Atlanta, Georgia, 30333

R. H. Hill Jr. Toxicology Branch, Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Services, U.S. Department of Health and Human Services, Atlanta, Georgia

D. L. Orti Toxicology Branch, Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Services, U.S. Department of Health and Human Services, Atlanta, Georgia

D. G. Patterson Toxicology Branch, Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Services, U.S. Department of Health and Human Services, Atlanta, Georgia

R. D. Kimbrough Toxicology Branch, Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Services, U.S. Department of Health and Human Services, Atlanta, Georgia

D. F. Groce Toxicology Branch, Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Services, U.S. Department of Health and Human Services, Atlanta, Georgia

J. A. Liddle Toxicology Branch, Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Services, U.S. Department of Health and Human Services, Atlanta, Georgia

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Abstract

A polybromlnated biphenyl (PBB) mixture was fractionated by normal‐phase preparative high‐performance liquid chromatography. The hexane fractions were concentrated and applied to rabbit ears. Only the most polar fraction produced hyperkeratosis on the rabbit ears. This active fraction was subfractionated by using the same procedure. Again, the extent of hyperkeratotic activity increased with increasing polarity. The PBBs of the largest concentration levels in the active fraction were purified by preparative gas chromatography and tested on rabbit ears. The major compounds did not demonstrate hyperkeratotic activity.

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Investigation of hyperkeratotic activity of polybrominated biphenyls in firemaster FF‐1

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Investigation of hyperkeratotic activity of polybrominated biphenyls in firemaster FF‐1

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