Subchronic inhalation toxicity of 1,3‐dichloropropene/1,2‐dichloropropane (D‐D) in mice and rats

Abstract

Groups of 28 male and 28 female CD‐1 mice and Fischer 344 rats were exposed to a mixture of 1,3‐Dichloropropene and 1,2‐Dichloropropane (D‐D) vapors. Exposure concentrations were 0, 5 (4.7), 15 (14.4), or 50 (53.7) ppm, 6 h/d, 5 d/wk for 6 or 12 wk. The following parameters were evaluated: pharmacotoxic signs, body weights, hematology (HGB, HCT, RBC, WBC, and diff. leukocyte count), serum chemistry (BUN, GLU, ALB, GPT, and ALP), urinalysis, gross pathology, histopathology, organ weights, and organ weight/body weight ratios of brain, heart, liver, kidneys, testes or ovaries, and adrenals. The only exposure‐related clinical effects observed were increased mean liver/body weight ratios of male rats and mean kidney/body weight ratios of female rats at the 50 ppm exposure level. Slight to moderate diffuse hepatocytic enlargement in 12 of 21 of the 50‐ppm male mice after 12 wk exposure was the only compound‐related histopathologic change present.