The biodistribution and metabolic fate of [¹¹C] acrylic acid in the rat after acute inhalation exposure or stomach intubation

Abstract

Rats were nose‐exposed to an atmosphere containing gaseous [¹⁴C] acrylic acid for 7 min and sacrificed 1.5 and 65 min later. At 1.5 min 28% of the administered radiolabel was associated with the snout of the exposed animal. The biodistribution data indicated the gastrointestinal tract as the major site of absorption of acrylic acid after inhalation exposure. ThereforeJunrats were also stomach intubated with an aqueous solution of f[¹¹C]acrylic acid and sacrificed at 1.5, 10, 20, 40, and 65 min after intubation. The absorption of acrylic acid from the stomach was rapid, as was its subsequent metabolism. Carbon‐11 was rapidly eliminated from both nose‐exposed and stomach‐intubated animals as ¹¹CO₂, with about 60% of the administered dose eliminated 1 h after administration. A portion of the radiolabel was also eliminated via the renal system.