![Sample our Environment & Sustainability journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5935/TOC-Subject-Sample-2021-Environment-Sustainability.jpg"})
Abstract
The effect of atropine, 2‐pyridine aldoxime methiodide (2‐PAM), and several O,O,O‐tri‐alkylphosphorothioates on poisoning of rats by a series of O,O‐dimethyl and O,O‐diethyl S‐alkyl phosphorothioates was investigated. Atropine and 2‐PAM successfully protected rats treated with O,O‐diethyl S‐n‐propyl and S‐i‐propyl phosphorothioates, while the O,O,O‐trialkyl phosphorothioates were effective in protecting rats treated with O,O‐dimethyl S‐methyl and S‐ethyl phosphorothioates. O,O‐Dimethyl and O,O‐diethyl S‐i‐propyl phosphorothioates also were examined for in vitro and in vivo inhibition of rat plasma, red blood cell, and brain cholinesterase. Overall, the results indicated that two different mechanisms, cholinergic and noncholinergic, are involved in intoxication by the O,O,S‐trialkyl phosphorothioates.