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Abstract
A pharmacokinetic model was developed to describe the disposition of lead in the rat. The model can be used to predict the effect of acute high‐dose as well as low‐dose exposure to lead. These results suggest that the model should be able to predict the effect of chronic low‐dose exposures as well. Plasma, bone, liver, and bile profiles were generated from this model using previously published data. The results obtained supported the existing theory that lead demonstrates a dose‐dependent pharmacokinetic profile in the rat.