Enhanced withdrawal from chickens of hexachlorobenzene (hcb) and pentachlorophenol (PCP) by mineral oil, and/or restricted feeding

Abstract

Young chickens fed hexachlorobenzene (HCB) or pentachlorophenol (PCP) for 14 d at 10 ppm in the diet contained body burdens of 573 or 362 μg, respectively. These diets were withdrawn (d 0) and replaced for 21 d with diets containing 5% mineral oil (MO), or 5% (CO), a bile‐acid‐binding resin, or the chickens were restricted in feed intake to 50% of controls (50‐RF), fed MO plus 50‐RF, or CO plus 50‐RF. Without any treatment during withdrawal, body burdens were reduced to 63% and 70% of the d 0 values for HCB and PCP, respectively. MO, CO, or 50‐RF reduced body burdens of HCB to 37% of d 0 burdens, but the combination treatments with 50‐RF reduced body burdens to 19% of d 0 values. PCP was at 35% of the d 0 burdens from 50‐RF, while all other treatments had reduced body burdens to nondetectable amounts of less than 0.7 μglbird by d 21 of withdrawal. Body fat was not reduced by mineral oil, but was reduced to some extent by CO, and was markedly reduced by 50‐RF. 50‐RF always reduced body burdens of PCP or HCB alone or in combination with MO or CO. These data are discussed in relationship to the nonbiliary excretion of xenobiotics.