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Original Articles

Metabolism and nephrotoxicity of tetralin in male Fischer 344 rats

, , , , &
Pages 267-275 | Received 09 Mar 1988, Accepted 13 Sep 1988, Published online: 20 Oct 2009
 

Abstract

Tetralin, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1‐tetralol, 2‐tetralol, 2‐hydroxyl‐1‐tetralone, 4‐hydroxyl‐1‐tetralone, 1,2‐tetralindiol, and 1,4‐tetralindiol. Rats treated with tetralin demonstrated the classic lesions of hydrocarbon‐induced nephropathy.

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