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Abstract
Indan, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1‐indanol, 2‐indanol, 5‐indanol, 1‐indanone, 2‐indanone, 2‐hydroxy‐1‐indanone, cis‐1,2‐indandiol, and trans‐1,2‐indandiol. The metabolites were identified using the techniques of gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The rats treated with indan demonstrated the classic lesions of hydrocarbon‐induced nephropathy. The kidney damage produced was less than that found for tetralin and other branched‐chain acyclic hydrocarbons.
