MUC1/CD227 IMMUNOHISTOCHEMISTRY IN ROUTINE PRACTICE IS A USEFUL BIOMARKER IN BREAST CANCERS

Abstract

Over-expression of MUC1/CD227 is observed in 90% of breast tumors. Classical morphologic description and semi-quantitative digital measurement of MUC1 were performed from immunohistochemical stained slides of 123 routine histological samples. Measures of MUC1 expression showed statistical differences between non tumoral (NT) breast tissue and Ductal Carcinoma In Situ (DCIS) or infiltrating carcinoma (IC), p < 0.0001. Loss of MUC1 was correlated with high Ki67 index (p = 0.001) and loss of hormonal receptors (p = 0.03), whereas no correlations were found with HER2 expression. High-grade DCIS or IC showed increasing loss of apical polarised and cytoplasmic expression of MUC1.

Keywords:

• Biomarker
• breast cancer
• cancer prognosis
• cancer therapy
• CD227
• immunohistochemistry
• MUC1
• Mucins

Notes

N: number of cases; Age: mean +/− SD (years); Ki67: mean +/− SD (%); ER: mean +/− SD of Allred's score for oestrogen receptors; PR: mean +/− SD of Allred's score for progesterone receptors; score of HER2: mean +/− SD of HER2 score.

Significant difference are notified by *(p < 0.01).

Significant difference are notified by *(p < 0.01).