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Original Articles

DETECTION OF ANTIBODIES TO THE 20S PROTEASOME BY ELISA

, , &
Pages 384-392 | Published online: 16 Jul 2013
 

Abstract

The presence of antibodies against the 20S proteasome has been correlated with diseases like multiple sclerosis (MS) and systemic lupus erythematosus (SLE) but no definite association has been established. In order to investigate this further, we optimized an ELISA for proteasome antibodies and applied it to test a total of 324 serum and plasma samples from MS patients, SLE patients, and healthy controls. Our results yield a functional and reliable assay but no correlation between the amount of proteasome antibodies present and the development of MS or SLE could be established.

Notes

IgG-index available for a 51 of 69 samples and b 56 of 67 samples. ND: not determined

ON = optic neuritis, OCB + = oligoclonal band positive.

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