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Journal of Immunoassay and Immunochemistry Volume 40, 2019 - Issue 1: Special Issue: Updates in Immune-Based Multiplex Assays
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Articles

Assessment of efficacy of dendritic cell therapy and viral therapy in high grade glioma clinical trials. A meta-analytic review

Bogdan Ionel VatuDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
,
Stefan-Alexandru ArteneDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
,
Adeline-Georgiana StaicuDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
,
Adina Turcu-StiolicaDepartment of Biostatistics, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
,
Catalin FolcutiDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
,
Alexandra DragoiDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
,
Catalina CiocDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
,
Stefania-Carina BaloiDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
,
Ligia Gabriela TataranuDepartment of Neurosurgery, Carol Davila, University of Medicine and Pharmacy, Bucharest, RomaniaView further author information
,
Cristian SilosiDepartment of Surgery, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaView further author information
&
Anica DricuDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, RomaniaCorrespondence[email protected]
View further author information
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Pages 70-80 | Published online: 30 Nov 2018
 
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ABSTRACT

In recent years, immunotherapy has raised the interest of many studies and provided different perspectives for the therapeutic management of high grade glioma. Our meta-analysis focused on the effectiveness of dendritic cell (DC) therapy and viral therapy (VT) in clinical trials. Fourteen eligible studies have been evaluated and the results suggest the improvement of both OS (HR = 0.65) (p < 0.0001) and PFS (HR = 0.59) (p = 0.01) for patients receiving DC therapy. The data for VT showed a slight improvement in terms of OS (HR = 0.81), while PFS was similar to the control arms (HR = 1.06) (p = 0.41).

Additional information

Funding

This work was supported by the UEFISCDI, Romania through the PN-II-ID-PCE-2011–3–1041 Grant.

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