The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis

ABSTRACT

Introduction: PIAS1 and PIAS2 (protein inhibitor of activated STAT 1,2) play key roles in the pathogenesis of autoimmune and inflammatory diseases. This study aims to evaluate the gene expression of these factors in multiple sclerosis (MS) patients compared to healthy individuals and correlate them with the severity of MS.

Materials and methods: Sixty participants, including 30 patients with MS and 30 healthy controls were studied. The expression of PIAS1 and PIAS2 genes in peripheral blood samples of all participants was measured by real-time PCR. The severity of MS was evaluated using the Expanded Disability Status Scale (EDSS). Finally, we evaluated the correlation between the expression of PIAS1 and PIAS2 genes with disease severity.

Results: The expression of PIAS1 gene was increased in patients with MS compared to healthy subjects (P value<.001). Also, there was a significant correlation between the expression of PIAS1 and PIAS2 genes with disease severity according to EDSS.

Conclusion: Our study suggests the expression of PIAS1 and PIAS2 genes as a prognostic and diagnostic marker in MS disease.

KEYWORDS:

• Multiple sclerosis
• PIAS1
• PIAS2
• EDSS

Acknowledgments

This study was originated from the studies related to a research supported by Deputy of Research, Kashan University of Medical Sciences (kaums), Grant No. 96162.

Declaration of interest

The authors declare no conflict of interest.

Authors’ contributions

HN contributed in the conception or design of the work, analysis and drafting of the manuscript. EK, HA, and SA contributed in conception and manuscript drafting. The final version was confirmed by all authors for submission