Neuroprotective effects of probiotics bacteria on animal model of Parkinson’s disease induced by 6-hydroxydopamine: A behavioral, biochemical, and histological study

ABSTRACT

Parkinson’s disease (PD) is an age-associated, progressive, and common neurodegenerative disorder. It is characterized by dopaminergic neuron degeneration in the substantia nigra pars compacta. The involvement of oxidative stress, inflammation, and dysbiosis in PD has been confirmed and probiotics also have the ability to regulate the mentioned mechanisms. Here, we assessed probiotics supplementation effects on experimental model of PD. Thirty Male Wistar rats were divided into three groups for a 14-day treatment. It was shown that a mixture of probiotics containing Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus reuteri, and Lactobacillus fermentum could improve rotational behavior, cognitive function, lipid peroxidation, and neuronal damage in the group received probiotic supplementation compared to the other groups (P < 0001, P < .001, and P = .026, respectively). Taken together, these findings revealed that probiotics supplementation could be an appropriate complementary treatment for PD.

KEYWORDS:

• Parkinson’s disease
• probiotic
• therapy

Author contributions

EA-N, O-RT, ZA, PS, MG, AA-T, MT, ZB, RH and MN-T contributed in the conception or design of the work and drafting of the manuscript. All authors confirmed the final version for submission.

Declaration of Interest

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by the Kashan University of Medical Sciences [96180].