Hormones, oxidized proteins, and lipids in alcoholism. Duration of remission

Abstract

The instability of remission in alcohol dependence (AD) creates a need to search for criteria for predicting its duration. The aim of study was to determine the hormones, oxidized proteins, and lipids in patients with AD, and the possible relations between these parameters and the duration of remission. Blood samples were obtained from 49 male patients with AD after alcohol detoxification (Total group). Two groups of patients were formed: with unstable therapeutic remission up to 6 months (UTR-group); with stable therapeutic remission which lasted 12 months or longer (STR-group). The control group comprised men without AD. The levels of carbonylated proteins (CP), lipid peroxidation (TBA-RS) were determined in the blood plasma. The levels of cortisol, testosterone total, thyroid-stimulating hormone (TSH), triiodothyronine free (fT3), and thyroxine free (fT4) in the blood serum were measured. The Total group of patients showed an increase in CP, TBA-RS, Cortisol, cortisol/testosterone ratio, and a decrease in TSH, fT3, and fT3/fT4 levels. A set of parameters (T, fT3, fT4, cortisol/testosterone ratio) associated with unstable remission was identified.

Keywords:

• Alcohol dependence
• remission
• carbonylated proteins
• lipid peroxidation substances
• hormones

Acknowledgments

The authors thank Marina Arzhanik, Associate Professor, Department of Medical and Biological Cybernetics, Siberian Medical University, Tomsk, Russia, for consultation on statistical analysis.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The research was funded by the Russian Foundation for Basic Research grant No. 18-44-700002. This study was also partially supported by the Institute of Mental Health (No. 075-01392-23-00, the research topic “Multidisciplinary study of clinical heterogeneity and pathobiological mechanisms of the progressive development of addictive disorders with the development of innovative programs for therapy and differentiated prevention,” registration number 122020200053-1).