Water-soluble [60] fullerene derivatives as potential chelating agents of radionuclides via chlorofullerene (C₆₀Cl₆) as a precursor

ABSTRACT

The reactions of catecholamide ligands with hexachlorofullerene via O-nucleophiles yielded new water-soluble [60] fullerene derivatives as chelators for radionuclides decorporation. The derivatives were characterized through ¹H NMR spectroscopy, FT-IR spectroscopy, and X-ray photoelectron spectroscopy. The affinities of the chelators were investigated through the fluorescence quenching of simulated nuclide Ce(III) via a linear Stern–Volmer plot method. Conditional stability constant (K) could also be estimated with this method. The antioxidant capacities of the chelators with a solubility of more than 150 mg/mL in water were examined through UV-vis spectroscopy by determining their 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. Results revealed that these chelators may be used for complexation, antioxidant activity, and radionuclide decorporation.

KEYWORDS:

• Hexachlorofullerene
• Modification
• Complexation
• Fluorescence quenching
• Antioxidant

Acknowledgments

We are grateful for financial support from the National Natural Science Foundation of China (Project No. 21301142, 51572230), Applied Basic Research Program of Sichuan Province (Project No. 2014JY0170), Open Project of State Key Laboratory Cultivation Base for Nonmetal Composites and Functional (Project No. 14zdfk05) and Southwest University of Science and Technology Outstanding Youth Foundation (Project No. 13zx9107).