Abstract
Antiapoptotic activity of NF-Kappa B (NF-κB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-κB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-κB DNA-binding activity as compared to the control group. No significant enhancement in NF-κB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-κB induced by chemotherapeutic drugs.