Preliminary Study of Pulsed-Electromagnetic Fields Effects on Endothelial (HUVEC) Cell Secretions—Modulation of the Thrombo-Hemorrhagic Balance

Abstract

We investigated the role of low-amplitude magnetic pulse with low repetition frequency superimposed on the environmental electromagnetic field (EMF) on the secretion of anti-aggregant (Prostacyclin or PGI₂) and pro-aggregant (Thromboxane A₂) agents in endothelial cells of the human umbilical cord vein (HUVEC).

We established that magnetic pulse exposure modulates both PGI₂ and TXA₂. These modulations depend on the frequency, width of the pulse, and intensity of the magnetic field. Moreover, we corroborated previous results obtained with an endothelial cell line (EaHy-926), concerning the increased thrombo-embolic risk for the 1 Hz frequency.

Keywords:

• Electromagnetic field
• HUVEC
• Thrombo-hemorrhagic balance