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ABSTRACT
The findings in this study were that the exposure of FG cells to nonylphenol (NP) caused decreases in the cell growth rate, antioxidant enzyme activities, and ATP content; an increase in intracellular O2− content; and alteration of the organelles such as mitochondria and the RER. It is proposed that the reduction in antioxidant enzyme activities leads to accumulation of O2− content, which in turn results in the damage of mitochondrial infrastructures and a decline in energy production, which then causes the ultrastructural alterations in the cells. In addition, we show that FG cells are a good candidate system for evaluation of NP acute toxicities.
| Abbreviations | ||
| BCS | = | bovine calf serum |
| CAT | = | catalase |
| GA | = | Golgi apparatus |
| GPX | = | glutathione peroxidase |
| L | = | lysozyme |
| M | = | mitochondrion |
| N | = | nucleus |
| NBT | = | nitroblue tetrazolium |
| NP | = | nonylphenol |
| Nu | = | nucleus |
| O2− | = | superoxide anion |
| PBS | = | phosphate-buffered saline |
| RER | = | rough endoplasmic reticulum |
| ROS | = | reactive oxygen species |
| SOD | = | superoxide dismutase. |
| Abbreviations | ||
| BCS | = | bovine calf serum |
| CAT | = | catalase |
| GA | = | Golgi apparatus |
| GPX | = | glutathione peroxidase |
| L | = | lysozyme |
| M | = | mitochondrion |
| N | = | nucleus |
| NBT | = | nitroblue tetrazolium |
| NP | = | nonylphenol |
| Nu | = | nucleus |
| O2− | = | superoxide anion |
| PBS | = | phosphate-buffered saline |
| RER | = | rough endoplasmic reticulum |
| ROS | = | reactive oxygen species |
| SOD | = | superoxide dismutase. |