Vitamin E supplementation modulates the biological effects of omega-3 fatty acids in naturally aged rats

Abstract

Omega-3 fatty acids are well-known class of nutraceuticals with established health benefits. Recently, the oxidation products of these fatty acids are gaining attention, as they are likely to disturb body redox balance. Therefore, the efficacy of omega-3 fats under conditions of diminished antioxidant status, such as aging, is always a concern. Present study assessed the effects of omega-3 fats (DHA and EPA) together with or without vitamin-E in naturally aged rats. It was found that in omega-3 fats alone consumed rats the lipid profile was improved, while in omega-3 fat with vitamin-E-consumed group (OMVE), the hepato protective and antioxidant properties were pronounced, especially the redox status of brain tissue. It is possible that vitamin-E might have reduced the peroxidation of omega-3 fats, thereby allowing their synergistic effects. Hence, the use of vitamin-E along with omega-3 fat may be beneficial under aged conditions.

Keywords:

• Omega-3 fatty acid
• vitamin E
• oxidative stress
• antioxidants
• aging

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

The study was financially supported by Indian Council of Medical Research under ad-hoc scheme [BMS/Adhoc/25/2012-2013, File No: 52/16/2011-BMS]. Arunaksharan N is also thankful to Council of Scientific and Industrial Research, India for the financial support as Senior Research Fellowship [09/869(0012)/2012-EMR-I]. Shaji EM expresses gratitude to University Grants Commission, India for the financial assistance as Faculty Development Program [FIP/12th Plan/KLCA044TF05]. Soorya PI acknowledges the receipt of Kerala State Council for Science Technology and Environment for financial assistance in the form of research fellowship [No. 01/FSHP MAIN/2015/KSCSTE].