Simple techniques to study multifaceted diabesity in the fly model

Abstract

Diabetes and obesity are the two notorious metabolic disorders in today’s world. Both diabetes and obesity are interlinked with each other and often referred to as ‘Diabesity’. It is a complex and multi-organ failure disorder. Thus, many researches and tremendous efforts have been made toward prevention, treatment as well as early detection of diabesity. However, and still, there is a large gap in understanding the etiology as well as treatment of diabesity. Various animal models are also used to decipher the mechanism underlying diabesity. Among all the model organism, recently Drosophila melanogaster is gaining its importance to study diabetes, obesity, and other metabolic disorder. Various experimental methods like histological, biochemical, developmental, and behavioral assays are described in this study to detect diabetes as well as obesity in the fly model.

Keywords:

• Diabetes
• obesity
• trehalose
• triglyceride
• drosophila melanogaster

Acknowledgements

We wish to thank two anonymous reviewers for their vaulable comments which help to improve the manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

NN is thankful to the DST-INSPIRE for financial assistance she received for her doctoral work. MM lab is supported by BT/PR21857/NNT/28/1238/2017, SERB/EMR/2017/003054 and Odisha DBT 3325/ST(BIO)-02/2017.