Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats

Abstract

We investigated the antihyperlipidemic effects of tyrosol in streptozotocin (STZ)-induced diabetic rats. Rats were injected intraperitoneally with STZ (40 mg/kg), and these established experimental rats were treated with tyrosol (20 mg/kg) and glibenclamide (600 µg/kg) for 45 days. The observed results revealed that tyrosol treatment significantly reduced plasma glucose, plasma, and liver total cholesterol, triglycerides, free fatty acids, phospholipids, plasma low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, and significantly increased plasma insulin and high-density lipoprotein cholesterol in STZ-induced diabetic rats. The activity of 3-hydroxy 3-methylglutaryl coenzyme A reductase significantly reduced in the liver, whereas the activities of lipoprotein lipase and lecithin cholesterol acyltransferase were significantly increased in the plasma of tyrosol treated STZ-induced diabetic rats. Histological examination showed that tyrosol treatment remarkably reduced lipid accumulation in the liver of STZ-induced diabetic rats. The present study revealed that tyrosol exhibits potent antihyperlipidemic effects in STZ-induced diabetic rats.

Keywords:

• Diabetes mellitus
• insulin
• lipids
• streptozotocin
• tyrosol

Acknowledgments

The authors thank the University Grants Commission (UGC), New Delhi, India, for funding support in the form of a research fellow under the Research Fellowship in Science for Meritorious Students (RFSMS) Scheme (F4-1/2006(BSR)/7-10/2007(BSR)) to Dr. R. Chandramohan.

Disclosure statement

The authors declare that they have no conflicts of interest concerning this article.