Evaluation of the protective effects of curcumin-rich turmeric (Curcuma longa) extract against isotretinoin-induced liver damage in rats

Abstract

Aim

The aim of this study was to evaluate the protective effect of curcumin-rich turmeric (CRT) extract against isotretinoin (ISO)-induced liver damage through routine biochemical parameters and oxidative stress parameters that indicate liver damage.

Material and Method

42 albino Wistar rats of 200 g were randomly grouped as Group I: Healthy control, Group II: Sunflower oil, Group III: Curcumin 200 mg/kg, Group IV: ISO control groups (7.5 mg/kg), Group V: Curcumin 50 mg/kg + ISO 7.5 mg/kg, Group VI: Curcumin 100 mg/kg + ISO 7.5 mg/kg, Group VII: Curcumin 200 mg/kg + ISO 7.5 mg/kg. At the end, after the rats were killed, their blood and liver tissues were collected. ALT and AST levels in serum; superoxide dismutase activity (SOD), GSH, and MDA levels in liver tissue were determined.

Results

Our results showed that ALT, AST, and MDA levels increased, and SOD and GSH levels decreased in the ISO-administered group compared to the healthy control group. CRT 50, 100, and 200 mg/kg groups were compared to ISO group. A dose-dependent increase in protective effect was observed. A decrease in ALT, AST, and MDA levels, and an increase in SOD and GSH levels were determined. A protective effect was found at all doses. The best protective effect was in the CRT 200 mg/kg group.

Conclusion

CRT extract can be considered a candidate herbal medicine for the elimination of liver damage in individuals using ISO. However, further experimental and clinical validation should be studied.

Keywords:

• Isotretinoin
• liver toxicity
• curcumin
• oxidative stress
• turmeric

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Correction

Author contribution

Nubar Nuriyeva and Yasin Bayir: Project development and project design

Emir Enis Yurdgulu, Kubra Aliyeva and Huseyn Aliyev: Conduct of experiments, analysis the data, and writing—original draft.

Abdulmecit Albayrak: Pharmacological additive to the interpretation of analysis

Ethical approval

All stages of our studies were approved in accordance with the ethical rules by the letter dated 27.12.2021 and numbered E-93722986-000-2100359379 issued by the "Atatürk University Animal Experiments Local Ethics Committee (AUHADYEK)".

Consent for publish

All authors give their consent for the publication of the results and tables within the text that will be published in the journal Toxicology Mechanisms and Methods.

Consent to participate

All authors equally participate in the study.

Consent for publication

All authors allow the publication of the paper.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data can be available upon request.

Correction Statement

This article was originally published with errors, which have now been corrected in the online version. Please see Correction (http://dx.doi.org/10.1080/15376516.2023.2268408)

Additional information

Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.