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Toxicology Mechanisms and Methods Volume 15, 2005 - Issue 2
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Toxicology Mechanisms

Changes in Gene and Protein Expression in Magnetic Field–Treated Human Glioma Cells

R. E. Savage Jr. National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, 45226
,
M. H. Kanitz National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, 45226
,
W. G. Lotz National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, 45226
,
D. Conover National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, 45226
,
E. M. Hennessey Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, 80523
,
W. H. Hanneman Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, 80523
&
F. A. Witzmann Department of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, 46202
 show all
Pages 115-120 | Received 03 Aug 2004, Accepted 27 Sep 2004, Published online: 09 Oct 2008
 
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Abstract

Because few cancer studies have examined protein profiles and genetic regulation from a single carcinogen exposure, the objective of this study was to determine genetic change via microarray and to evaluate whether that change was a precursor to cellular protein changes. In separate but experimentally identical studies, human glioma SF767 cells were exposed for 3 h to 60-Hz magnetic fields (sham or 1.2 μT). Microarray results suggested that magnetic field treatment resulted in the up-regulation of 5 genes, whereas 25 genes were down-regulated. The mean abundance of 10 identified proteins was altered following 1.2 μT exposure relative to sham (3 increase, 7 decrease). These studies suggest a limited but complicated response in the glioma cells to the magnetic field treatment.

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