Studies on hydroquinone based maleate bolaamphiphile organogels and their drug formulations

ABSTRACT

Now a day’s there is an upsurge in topical gel formulations, they can be prepared by varying physico-chemical methods and provide better localized action. A maleate based symmetric bolaamphiphile was synthesized by using cost-effective starting materials under mild reaction condition. The gelation ability of bolaamphiphile in aqueous medium was examined for a series of organic solvents. In hexane, the gelator showed better gelation ability with relatively higher critical strain (54 Pa) values. Further, the microscopic images of the gel revealed flakes like morphology, both the XRD and DFT studies revealed the presence of non covalent interactions. These gels showed a high internal-phase mole ratio of the topical drugs in the order of curcumin < salicylic acid < Ibuprofen. Formation of aqueous and organic gel-phase formulation may facilitate the topical medications for various applications related to ophthalmic and skin infections.

KEYWORDS:

• Drug formulation
• maleate based bolaamphiphile
• morphology
• organogel
• rheology

Electronic supplementary material

The supplementary material contains the synthesis scheme, gel photographs, DSC thermogram, control experiment of drug formulation and NMR sprectums. Supplementary data associated with this article is available in the online version.

Acknowledgments

This work was supported by the University Grant Commission (UGC), Government of India for Senior Research Fellowship. Authors are thankful to Ms. Y. Swarna Latha for her help in carrying out FE-SEM and XRD experiments. Author further acknowledge Prof Sabysachi Mishra, IIT, Kharagpur for his help in DFT calculations.

Declaration of interest

The authors report no conflicts of interest.

Supplemental data

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