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ABSTRACT
The aim of this study was to prepare novel bio-based maghemite (Fe2O3) nanocomposites as reduced graphene oxide (rGO)-doped Fe2O3 nanocomposites (Fe2O3/rGO NCs) and to investigate on their interaction with human serum albumin (HSA) as a natural polymer. Various photochemical and conformational techniques such as Fourier transform infrared spectrum, X-ray diffraction, Raman spectroscopy, scanning electron microscopes/energy-dispersive X-ray, circular dichroism, synchronous fluorescence spectroscopy, and resonance light scattering were used for characterizing the Fe2O3/rGO NCs and studying their interaction with HSA. The spectroscopic studies indicated that a complex formed between HSA and bio-based Fe2O3/rGO NCs induced structural changes on HSA. The helicity of HSA was decreased and the random coil and β-turn in the secondary structure of HSA were enhanced. In addition, the analysis of fluorescence spectra showed that Fe2O3/rGO NCs had a strong ability to quench the intrinsic fluorescence of HSA by static quenching mechanisms. It has been claimed that the bio-based production of nanomaterials possess no remarkable un-favored effects in biomedical fields of applications. However, the obtained results of our study demonstrate the deep influence of bio-based Fe2O3/rGO NCs on HSA.
Acknowledgments
The financial support by the Research Institute for Fundamental Sciences (RIFS), University of Tabriz is gratefully acknowledged. We also acknowledge drug Applied Research Center, Tabriz University of Medical Sciences where the photoluminescence experiments were done. In addition, we appreciate for grammatical modifications and language-supports of Dr Vartan Simmonds.
Conflict of interest
The authors declare no conflict of interest