Nitric Acid in the Presence of Supported P₂O₅ On Silica Gel Affords an Efficient and Mild System for Oxidation of Organic Compounds Under Solvent-Free Conditions

Abstract

This paper describes an efficient and easy method for oxidation of alcohols 1 and sulfides 2 to their corresponding carbonyl compounds 3 and sulfoxides 4 with nitric acid in the presence of supported P₂O₅ on silica gel under solvent-free conditions in high yields.

Keywords:

• is oxidation
• nitric acid
• solvent-free
• sulfoxide

Acknowledgments

The authors acknowledge support from the Isfahan University of Technology (IUT), IR Iran (A. R. H.), and financial support by the research affairs, Yazd University, Yazd, Iran. Additional financial support from Center of Excellency in Chemistry Research (IUT) is greatfully acknowledged.

Notes

^a Confirmed by comparison with authentic samples (IR, TLC and NMR) [35]

^b Yield of product after purification.

^a Confirmed by comparison with authentic samples [19-30].

^b Substrate/Oxidant (1:1.2 mmol).

^c Yield of isolated pure products.

^d 10% disulfoxide.

^e 15% disulfoxide.

^f 12% disulfoxide.