Abstract
We have investigated singlet oxygen generation and photocytotoxicity against tumor cells by two-photon excitation using a two-photon absorbing photosensitizer consisting of a butadiyne-bridged porphyrin dimer terminated with two water-soluble porphyrin monomers. The compound exhibited high efficiency for singlet oxygen generation under not only one-photon but also two-photon irradiating conditions. The successful destruction of Hela cancer cells via two-photon absorption (2PA) is demonstrated.
Acknowledgments
This work was supported by Grant-in-Aids for Scientific Research (A) (No. 15205020) and for Young Scientists (B) (No. 18750118) from Ministry of Education, Culture, Sports, Science and Technology (Monbu Kagakusho), by Terumo Lifescience Foundation and by Iketani Science Technology Foundation. K.O. acknowledges partial financial support from Kinki-Chiho Invention Center.