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Molecular Crystals and Liquid Crystals Volume 471, 2007 - Issue 1
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Organic Photovoltaics, Transistors, Light-Emitting Diodes and Other Devices

Singlet Oxygen Generation and Photocytotoxicity against Tumor Cell by Two-Photon Absorption

Kazuya Ogawa Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
,
Joanne T. Dy Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan
,
Yoshiaki Kobuke Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, JapanCorrespondence[email protected]
,
Shun-ichiro Ogura Department of Bioengineering, Tokyo Institute of Technology, Midori-ku, Yokohama, Kanagawa, Japan
&
Ichiro Okura Department of Bioengineering, Tokyo Institute of Technology, Midori-ku, Yokohama, Kanagawa, Japan
Pages 61-67 | Published online: 22 Sep 2010
 
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Abstract

We have investigated singlet oxygen generation and photocytotoxicity against tumor cells by two-photon excitation using a two-photon absorbing photosensitizer consisting of a butadiyne-bridged porphyrin dimer terminated with two water-soluble porphyrin monomers. The compound exhibited high efficiency for singlet oxygen generation under not only one-photon but also two-photon irradiating conditions. The successful destruction of Hela cancer cells via two-photon absorption (2PA) is demonstrated.

Acknowledgments

This work was supported by Grant-in-Aids for Scientific Research (A) (No. 15205020) and for Young Scientists (B) (No. 18750118) from Ministry of Education, Culture, Sports, Science and Technology (Monbu Kagakusho), by Terumo Lifescience Foundation and by Iketani Science Technology Foundation. K.O. acknowledges partial financial support from Kinki-Chiho Invention Center.

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