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Abstract
The therapeutic metabolites properties of microorganisms obtained from Monascus sp in solid state biosynthesis in submerged media were studied and are presented. Some products isolated from solid state biosynthesis or from submerged media, were investigated in order to establish their biological or physico - chemical properties. The primary tests performed in order to establish the antioxidant properties revealed a strong antioxidant capacity situated in the range (1420 ÷ 3700) mMol Trolox Equivalent/mg product for intracellular metabolites obtained in submerged media or in solid state biosynthesis. The immunomodulatory tests performed in vitro on a monocyte human cell line with two products isolated from solid state biosynthesis show the stimulation of human macrophage (by induction of the secretion of TNF-α and IL-6 with differentiate cell THP-1 type). The physico-chemical characteristics of investigated compounds performed by FT-IR spectroscopy show the presence of N glucosylrubropunctamine and N-glucosylmonascorubramine in biomaterials obtained by solid biosynthesis.