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Molecular Crystals and Liquid Crystals Volume 590, 2014 - Issue 1: Proceedings of the Ninth International Conference on Electronic Processes in Organic Materials (ICEPOM-9)
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ELECTRONIC PROCESSES IN ORGANIC MATERIALS: CHEMISTRY

Processes of Encapsulation and Crystallization of Prednisolon in PAAm-b-PEO-b-PAAm Micellar Solutions

Tatyana Zheltonozhskaya Taras Shevchenko National University of Kiev, Faculty of Chemistry, Department of Macromolecular Chemistry, 60 Vladimirskaya St, 01033, Kiev, Ukraine
,
Sofia Partsevskaya Taras Shevchenko National University of Kiev, Faculty of Chemistry, Department of Macromolecular Chemistry, 60 Vladimirskaya St, 01033, Kiev, Ukraine
,
Vasil Gorchev Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovycha St, 01601, Kiev, Ukraine
&
Dmytro Klymchuk Institute of Botany, National Academy of Sciences of Ukraine, 2 Tereschenkovskaya St., 01601, Kiev, Ukraine
Pages 140-148 | Published online: 28 Mar 2014
 
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Abstract

Micellar solutions of PAAm-b-PEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamide (Mn= 6 and 116 kDa) were applied to study the encapsulation of poorly soluble crystallizing drug prednisolon (PS) in a region of ϕ= 0.065 ÷ 0.39 molPS/base-molTBC. The equilibrium mechanism of the encapsulation and the effect of specific aggregation of small and large PS-loaded micelles by their “coronas” that promoted the drug crystallization were established. The fractal character of large drug-loaded micelles and unusual morphology of PS crystals allowed assuming the presence of TBC micelles inside crystalline space.

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